In vivo blockade of pemphigus vulgaris acantholysis by inhibition of intracellular signal transduction cascades
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چکیده
منابع مشابه
Pemphigus vulgaris acantholysis ameliorated by cholinergic agonists.
BACKGROUND Pemphigus vulgaris (PV) is an autoimmune, IgG autoantibody-mediated disease of skin and mucosa leading to progressive blistering and nonhealing erosions. Patients develop autoantibodies to adhesion molecules mediating intercellular adhesion and to keratinocyte cholinergic receptors regulating cell adhesion. OBSERVATIONS To determine whether a cholinergic agonist can abolish PV IgG-...
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The autoimmune blistering skin disease pemphigus vulgaris (PV) is caused primarily by autoantibodies against desmosomal cadherins. It was reported that apoptosis can be detected in pemphigus skin lesions and that apoptosis can be induced by PV-IgG in cultured keratinocytes. However, the role of apoptosis in PV pathogenesis is unclear at present. In this study, we provide evidence that apoptosis...
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Protease inhibitors prevent plasminogen-mediated, but not pemphigus vulgaris-induced, acantholysis in human epidermis.
Pemphigus is an autoimmune blistering disease of the skin and mucous membranes. It is caused by autoantibodies directed against desmosomes, which are the principal adhesion structures between epidermal keratinocytes. Binding of autoantibodies leads to the destruction of desmosomes resulting in the loss of cell-cell adhesion (acantholysis) and epidermal blisters. The plasminogen activator system...
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The mitogen-activated protein kinase (MAPK) cascade is a highly conserved signaling module comprised of three sequentially activated protein kinases, which are rapidly phosphorylated near the membrane and dephosphorylated in the cytosol. It regulates various important biological processes including differentiation, proliferation, and synaptic plasticity. In this paper, a diffusion-reaction mode...
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ژورنال
عنوان ژورنال: British Journal of Dermatology
سال: 2004
ISSN: 0007-0963,1365-2133
DOI: 10.1111/j.1365-2133.2004.06147.x